Echinococcosis

                                  Overview

                                  Echinococcosis is a parasitic disease that occurs in two main forms in humans: cystic echinococcosis (also known as hydatidosis) and alveolar echinococcosis, caused by the tapeworms Echinococcus granulosus and Echinococcus multilocularis, respectively.

                                  Dogs, foxes and other carnivores harbour the adult worms in their intestine and evacuate the parasite eggs in their faeces. If the eggs are ingested by humans, they develop into larvae in several organs, mainly the liver and lungs.

                                  Both cystic and alveolar echinococcosis are characterized by asymptomatic incubation periods that can last many years until the parasite larvae evolve and trigger clinical signs.

                                  Both diseases can cause serious morbidity and death.

                                  Symptoms

                                  Cystic echinococcosis is characterized by an asymptomatic incubation period that can last many years until the parasite cysts evolve and trigger clinical signs, depending on the location and size of the cysts and the pressure exerted on the surrounding tissues. In cystic echinococcosis, the larval stages of the parasite develop as one or more cysts mainly in the liver and lungs, and less frequently in the bones, kidneys, spleen, muscles, central nervous system and eyes. Abdominal pain, nausea and vomiting commonly occur when cysts invade the liver. If the lung is affected, clinical signs include chronic cough, chest pain and shortness of breath.

                                  Alveolar echinococcosis is characterized by an asymptomatic incubation period of 5–15 years and the slow development of a primary tumour-like lesion which is usually located in the liver. Lesions may also involve other organs such as the spleen, lungs and brain following dissemination of the parasite via the blood and lymphatic system. Clinical signs include weight loss, abdominal pain, general malaise and signs of hepatic failure. If left untreated, alveolar echinococcosis is progressive and fatal.


                                  Treatment

                                  Both cystic echinococcosis and alveolar echinococcosis can be expensive and complicated to treat, sometimes requiring extensive surgery and/or prolonged drug therapy. The treatment used should be decided based on results from ultrasound images of the cyst. Treatments can include percutaneous treatment of the hydatid cysts with the PAIR (Puncture, Aspiration, Injection, Re-aspiration) technique, surgery, anti-infective drug treatments or simply watching and waiting.  

                                  Human cystic echinococcosis is diagnosed with imaging tools such as ultrasound or computed tomography, and its laboratory confirmation relies on serological tests.

                                  Diagnosis of alveolar echinococcosis is based on clinical findings and epidemiological data, imaging techniques, histopathology and/or nucleic acid detection, and serology. Early diagnosis and radical (tumour-like) surgery followed by anti-infective prophylaxis remain the key elements. If the lesion is confined, radical surgery offers cure. Unfortunately, in many patients the disease is diagnosed at an advanced stage, and palliative surgery, if carried out without or with incomplete anti-parasitic treatment, frequently results in relapses.

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                                  Foodborne parasitic infections: Cystic and alveolar echinococcosis
                                  Human echinococcosis is a zoonotic disease caused by parasites of the genus Echinococcus. Of the several species worldwide, the two most important in humans...
                                  Meeting of the WHO Informal Working Group on Echinococcosis (WHO-IWGE)

                                  The WHO Department for Control of Neglected Tropical Diseases and the newly appointed co-chairs of the WHO Informal Working Group on Echinococcosis (WHO-IWGE)...

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                                  Hydatid disease, otherwise known as cystic echinococcosis (CE), is caused by Echinococcus granulosus. The disease is common in many pastoral areas,...